The network is due to air documentary Right To Die this evening (December 10), in which it will screen the last living moments of 59-year-old motor neurone sufferer Craig Ewert.
Euthanasia charity Dignitas assisted the former university lecturer's suicide, but Sky's decision to broadcast the precise moment of his death has stirred up intense controversy about media boundaries.
While assisted suicide is illegal in Britain, several organisations facilitate euthanasia by arranging transport of chronically ill people to Switzerland, where the practice is allowed.
That loophole itself remains a controversial subject, but Sky's decision to film and broadcast Mr Ewert's final breath has inflamed public opinion to such a degree that Whitehall has now stepped in.
"I think it's very important that these issues are dealt with sensitively and without sensationalism," the prime minister sombrely said during a debate about the TV show at MPs Question Time.
But he avoided directly criticising Sky for promoting macabre voyeurism, instead going on to speak about how these "very difficult issues" evoke strongly-held beliefs on both sides of the House.
Justifying his decision to oppose legislation for assisted suicides, Mr Brown also reiterated his concern that liberalising the law might create a situation where a sufferer "feels under pressure" to die.
Barbara Gibbon of the Sky Real Lives channel defended the TV programme. She said the "honest and impartial documentary" upheld the broadcaster's duty to "inform public debate about even the most challenging subjects".